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TOPIC: Insubolic (IGF-1) + Qtropin(HGH).

Insubolic (IGF-1) + Qtropin(HGH). 1 year 6 days ago #13963

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HGH therapy reduce Insulin sensitivity, IGF-1 enhance insulin sensitivity, both medications promote protein anabolism, lipolysis and lipid oxidation and reduce protein oxidation by different mechanism. The study suggests that combined use of IGF-1 and HGH has great potential and synergistic effect.

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Insulin-like growth factor-I ( IGF-I) is considered to be the mediator of the growth-promoting effects of growth hormone ( GH). The metabolic effects of these two hormones, however, are different. Whereas GH treatment leads to elevated insulin and glucose levels, reduced insulin sensitivity, and impaired glucose tolerance, IGF-1 treatment leads to reduced insulin and GH levels and enhanced Insulin sensitivity. IGF-I may, therefore, not only be the mediator of the growth-promoting effects of GH but also a modulator of the effects of GH on insulin action and glucose metabolism. To study the influence of GH and IGF-I on substrate metabolism and insulin sensitivity (assessed by euglycemic, hyper-insulinemic clamping combined with indirect calorimetry and glucose tracer infusion), we have treat. eight GH-deficient adults with GH (2 IU/m. daily subcutaneously fs.c.)), 1GF-1 (10 mcg/kg • h s.c.), or both hormones together for 7 d, respectively, and compared the effects of these treatment regimens
with a control phase. Our findings suggest that (a) both GH and IGF-I promote lipolysis and lipid oxidation, albeit by different mechanisms; (b ) treatment with either hormone is followed by enhanced energy expenditure and reduced protein oxidation; and (e) IGF-I reverses the insulin resistance induced by GH. (J. Clin. Invest. 1994.94:1126-1133.)


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Effects of GH and IGF-1 on protein oxidation.
Reduction of protein oxidation, i.e., of proteolysis, was observed under IGF-I as well as GH treatment. When both hormones were given together, the effects of IGF-I and GH were additive. These findimgs support those of a previous report also showing that anabolism may be stimulated to a greater extent by treatment with GH and IGF-I together than by either hormone alone (40). Moreover, insulin-like properties of IGF-I 30) and the fact that IGF-I increases insulin sensitivity of skeletal muscle may allow us to preserve normal glucose tolerance when GH and IGF-I stimulate protein anabolism in a concerted fashion.

In conclusion, our results show that IGF-I per se is a potent anticatabolic agent (as in regard to protein metabolism) leading by way of partial inhibition of insulin secretion to increased lipolysis and fat oxidation. These effects of IGF-I are indepenedent of the inhibitory effect on growth hormone secretion. All these effects of IGF-1 are, however, synergistic to those of GH, which stimulates lipolysis and possibly protein anabolism through mechanisms different from those of IGF-1. In the case of simultaneous administration of GH and IGF-1, insulin levels lie between those attained by IGF-I treatment alone and those observed during GH treatment. Since insulin is an important anabolic hormone (41), it is conceivable that in situations of severe catabolism a combination of GH and IGF-I together will turn out to give the best results with regard to anticatabolism and anabolism (40).


www.ncbi.nlm.nih.gov/pmc/articles/PMC295178/?page=1
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Insubolic (IGF-1) + Qtropin(HGH). 1 year 6 days ago #13964

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Let me sum it up : HGH + IGF-1 is better than HGH or IGF-1 alone.
Better in terms of therapeutic effects, better for health.
HGH may reduce Insulin sensitivity, while IGF-1 elevates insulin sensitivity. Normally, HGH is used for an extended period of time : 6 months + or even non-stop, adding IGF-1 to your HGH cycle, even at low dosages will deliver some additional benefits for your health and performance.
Look at the panel above :
Glucose, Insulin look more balanced in the IGF-1 +HGH group
Higher HGH serum and IGF-1 level in the IGF-1+ HGH group as well, which proves it's synergy.
Some athletes use insulin with HGH when dosages exceed 6-7 IU's/day or lower, I see the potential of replacing it with IGF-1.
The study proves that IGF-1 isn't just a by-product of HGH and HGH isn't just a medication used to stimulate IGF-1 release by our liver, but substances that have many things in common but work through different mechanisms.
Last Edit: 1 year 6 days ago by Administrator.
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Insubolic (IGF-1) + Qtropin(HGH). 1 year 6 days ago #13967

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We'll roll out this packaging by the end of August.
Last Edit: 1 year 6 days ago by Administrator.
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Insubolic (IGF-1) + Qtropin(HGH). 11 months 2 weeks ago #14005

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Been running HGH + IGF-1 for some time now, as a long time user of HGH, I can say I love this stack. One of my friends, who couldn't run HGH at dosages higher than 2 IU's/day due to extreme bloating, after adding IGF-1 he's at 5 IU's/day now with zero bloating.
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Insubolic (IGF-1) + Qtropin(HGH). 10 months 2 weeks ago #14089

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The metabolic effects of human growth hormone may be segregated into two classes which can be termed “insulinlike” (or “anabolic”) and “contra-insulin” (or “diabetogenic”). It is proposed that the “anabolic” actions of HGH are optimized by the presence of insulin, whereas the “diabetogenic” actions are dominant in the absence of insulin. In line with this notion, the sequential release of insulin and of HGH which follows protein ingestion, or aminoacid infusion may serve to route aminoacid toward protein, while buffering changes in plasma glucose concentration.

Many of us don't want to deal with insulin to get the highly praised HGH-Insulin cycle results.
IGF-1 binds to insulin receptors too (with a low affinity), so it can be a great replacement to insulin in this regard.



www.ncbi.nlm.nih.gov/pmc/articles/PMC5642081/
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Insubolic (IGF-1) + Qtropin(HGH). 10 months 1 week ago #14098

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Thanx for the info! u just sold me on the hgh+igf1 combo. i can only run about 2ius og hgh/day also due to EXTREME bloating. i cannot even wear my shoes! so hopefully the combo of the 2 is the answer.
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